Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul
Transgene Detail

Summary

• Symbol: Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul
• Name: transgene insertion Db-1, William Muller
• MGI ID: MGI:3614340
• Synonyms: MMTV/MT-Y315/322F, MMTV-PyVmT Y315/322F, Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul
• Transgene: Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul Location: unknown
• Alliance: Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene expresses mutant plyomavirus middle T antigen with Y to F mutation at position 315 and 322 under the control of the mouse mammary tumor virus LTR. Expression of this transgene was detected at high levels in male and female mammary glands. Other expression sites include salivary gland, seminal vesicles, ovaries, and lung. (J:56327)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Total of 7 lines were produced, of which six lines Db-1, Db-3, Db-4, Db-5, Db-6 and Db-7 had similar phenotype. These mice were used to study metastatic disease and they had similar phenotype.

References

• Original: J:56327 Webster MA, et al., Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol. 1998 Apr;18(4):2344-59
• All: 6 reference(s)