Tg(Ela1-Bhlhb8)#Skz
Transgene Detail

Summary

• Symbol: Tg(Ela1-Bhlhb8)#Skz
• Name: transgene insertion #, Stephen F Konieczny
• MGI ID: MGI:3614384
• Synonyms: Elastasepr-Mist1^MB, elastasepr-Mist1^myc, Mist1^MB
• Transgene: Tg(Ela1-Bhlhb8)#Skz Location: unknown
• Alliance: Tg(Ela1-Bhlhb8)#Skz page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene consists of the rat elastase 1 promoter driving expression of a dominant negative mutation of the mouse Bhlhb8 gene. The mutation was created by replacing RER with GGG in the basic domain at amino acids 80-82. The construct also contains a C-terminal Myc epitope tag. Eight lines were generated some with patchy expression and others with expression in 95% of pancreatic acinar cells. In J:89063 phenotypic data was only provided for lines with patchy expression. (J:89063)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:89063 Zhu L, et al., Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia. Mol Cell Biol. 2004 Apr;24(7):2673-81
• All: 3 reference(s)