Ccnd1^tm1Phin
Targeted Allele Detail

Summary

• Symbol: Ccnd1^tm1Phin
• Name: cyclin D1; targeted mutation 1, Philip W Hinds
• MGI ID: MGI:3614415
• Synonyms: cyclin D1^KE
• Gene: Ccnd1 Location: Chr7:144483668-144493568 bp, - strand Genetic Position: Chr7, 88.92 cM
• Alliance: Ccnd1^tm1Phin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105045
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert a point mutation into exon 2 that resulted in a K112E substitution. Crossing with mice expressing cre recombinase removed a floxed neo cassette. Normal levels of protein were found in mutant heart, lung, spleen, liver and kidney samples. A slower-migrating protein was detected in mutant tissues. (J:105045)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnd1 Mutation: 22 strains or lines available

References

• Original: J:105045 Landis MW, et al., Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell. 2006 Jan;9(1):13-22
• All: 3 reference(s)