Kiss1r^tm1Gstn
Targeted Allele Detail

Summary

• Symbol: Kiss1r^tm1Gstn
• Name: KISS1 receptor; targeted mutation 1, Eric L Gustafson
• MGI ID: MGI:3614434
• Synonyms: GPR54^-
• Gene: Kiss1r Location: Chr10:79752805-79758107 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Kiss1r^tm1Gstn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102113
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 52 bp fragment of exon 2 was replaced with an IRES-lacZ insert. Northern blot analysis confirmed a lack of detectable expression of the transcript in brain, kidney and liver. (J:102113)

Disease models

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kiss1r Mutation: 21 strains or lines available

References

• Original: J:102113 Funes S, et al., The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Biochem Biophys Res Commun. 2003 Dec 26;312(4):1357-63
• All: 5 reference(s)