Tg(APOA1)427Bres
Transgene Detail

Summary

• Symbol: Tg(APOA1)427Bres
• Name: transgene insertion 427, Jan L Breslow
• MGI ID: MGI:3614555
• Synonyms: hA-I^Tg, Tg(OHSA-AI)427
• Transgene: Tg(APOA1)427Bres Location: unknown
• Alliance: Tg(APOA1)427Bres page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOA1)427Bres expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOA1 (335)

  Apoa1

  (MGI:88049)

• Mutation details: The transgene construct was composed of a 2.2 kb genomic clone of the human gene and contained 256 bp of 5' sequence. Ten to 50 copies were inserted. The human gene is expressed in liver but not in intestine, testis, or ovary. Average human APOA-I levels are 339mg/dl. (J:94253)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:94253 Walsh A, et al., High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3. J Biol Chem. 1989 Apr 15;264(11):6488-94
• All: 13 reference(s)