Zap70^mrtle
Chemically induced Allele Detail

Summary

• Symbol: Zap70^mrtle
• Name: zeta-chain (TCR) associated protein kinase; mr t-less
• MGI ID: MGI:3614790
• Synonyms: Zap70^mrt
• Gene: Zap70 Location: Chr1:36800912-36821899 bp, + strand Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
• Alliance: Zap70^mrtle page

Mutation origin

• Strain of Origin: C57BL/6JSfdAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: This phenotypic mutation, identified in an ENU mutagenesis screen, is a T-to-C transition at nucleotide position 1601 that results in replacement of tryptophan by arginine at amino acid position 504 of the protein (W504R), which resides in the kinase domain. The level of the protein in homozygous and heterozygous mutant thymocytes is approximately 25% and 50% that in wild-type thymocytes, respectively.
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Zap70 Mutation: 55 strains or lines available

References

• Original: J:104190 The Australian Phenomics Facility at The Australian National University, Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University. MGI Direct Data Submission. 2006-2014
• All: 6 reference(s)