Hom1^A/Ph
QTL Variant Detail

Summary

• QTL variant: Hom1^A/Ph
• Name: hormone metabolism 1; A/Ph
• MGI ID: MGI:3614829
• QTL: Hom1 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: A/Ph

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased plasma testosterone, increased testosterone binding capacity, increased testes weight, and decreased vesicular gland weight compared to C57BL/10ScSnPh. (J:5301, J:5336)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:5301

An H2-linked locus named Hom1 (hormone metabolism 1) on mouse Chromosome 17 affects plasma testosterone concentration and testosterone binding capacity. The congenic B10.A-H2^a line carries A/Ph-derived DNA at the H2 locus (including Hom1) on a C57BL/10ScSnPh genetic background and exhibits higher plasma testosterone and testosterone binding capacity compared to C57BL/10ScSnPh. Analysis of (A/Ph x B10.A-H2^a)F2 animals showed that inheritance of A/Ph-derived alleles at the H2 locus confer increased plasma testosterone and testosterone binding capacity. This observation supports the existence of Hom1 located at approximately 23 cM on mouse Chromosome 17.

J:5336

Male animals from B10.A-H2^a congenics and (A/Ph x C57BL/10ScSnPh)F2 and (AKR x C57BL/10ScSnPh)F2 intercrosses were analyzed for testes weight and vesicular gland weight. The B10.A-H2^a congenic carries A/Ph-derived DNA at the H2 locus on a C57BL/10ScSnPh genetic background. A locus named Hom1 (hormone metabolism 1) is believed to reside near H2-K and influences plasma testosterone concentration and the size of testosterone-influenced organs, such as testes, thymus, and lymph nodes. F2 animals homozygous for A/Ph-derived alleles at Hom1 exhibit increased plasma testosterone concentration, increased testosterone binding capacity, increased testes weight, and decreased vesicular gland weight compared to C57BL/10ScSnPh parentals or F2 animals homozogygousfor C57BL/10ScSnPh-derived alleles. F2 animals inheriting AKR-derived alleles at Hom1 exhibit increased testes weight and decreased vesicular gland weight compared to F2 animals homozogyous for C57BL/10ScSnPh-derived alleles, but to a lesser degree than animals homozygous for A/Ph-derived alleles at Hom1. Comparison of B10.A-5R and B10.A-2R recombinant congenic strains places Hom1 near H2-K (18.65 cM) and Ir1 on mouse Chromosome 17.

References

• Original: J:5301 Ivanyi P, et al., Genetic association between H-2 gene and testosterone metabolism in mice. Nat New Biol. 1972 Aug 30;238(87):280-1
• All: 2 reference(s)