Rmp2^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Rmp2^DBA/2J
• Name: resistance to mousepox 2; DBA/2J
• MGI ID: MGI:3614837
• QTL: Rmp2 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to ectromelia virus compared to C57BL/6J. (J:11032)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:11032

Linkage to mousepox susceptibility was mapped in 101 male animals from a (C57BL/6J x DBA/2J)F1 x DBA/2J backcross inoculated with 10⁵ PFU of mouse ectromelia virus. Inbred strain DBA/2J is highly susceptible to infection with ectromelia virus whereas inbred strain C57BL/6J is resistant. Rmp2 (resistance to mousepox 2) and Rmp3 (resistance to mousepox 3) were identified near Hc (23.5 cM) on mouse Chromosome 2 and near H2-D (19 cM) on mouse Chromosome 17, respectively. Homozygosity for DBA/2J-derived alleles at Rmp2 and Rmp3 is associated with susceptibility to ectromelia virus infection and increased post-infection mortality.

10.8.2015 Curator Note: When previoulsy identified QTL are cited as confirmed or verified within the same study, using a different cross then that initially used, we have created a new QTL. We consider each distinct cross to be a separate mapping experiment. We have named the QTL identified here using the (C57BL/6NCr x DBA/2NCr)F1 x DBA/NCr backcross as Rmp5 and Rmp6 repectively.

Analysis of 66 males animals from a (C57BL/6NCr x DBA/2NCr)F1 x DBA/NCr backcross had similar results. When the experiment was repeated on gonadectomized and sham-operated male backcross animals, Rmp5 and Rmp6 were shown to confer additional protection against ectromelia virus in sham-operated animals. This finding indicates that Rmp5 and Rmp6 exhibit responsiveness to hormonal sexfactors. The complement component C3 (34.3 cM) maps near Rmp6. C3 is androgen-responsive and may be a possible candidate gene.

References

• Original: J:11032 Brownstein DG, et al., Chromosomal locations and gonadal dependence of genes that mediate resistance to ectromelia (mousepox) virus-induced mortality. J Virol. 1991 Apr;65(4):1946-51
• All: 1 reference(s)