Obwq1^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Obwq1^NZB/BlNJ
• Name: obesity and body weight QTL 1; NZB/BlNJ
• MGI ID: MGI:3614850
• QTL: Obwq1 Location: unknown Genetic Position: Chr1, cM position of peak correlated region/allele: 50.93 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight and increased mesenteric fat pad weight compared to SM/J. (J:103841)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Obwq1 maps to 62 cM on mouse Chromosome 1 near D1Mit87 (LOD=4.3) with the 95% confidence interval spanning approximately 24 cM - 64 cM. NZB/BlNJ-derived alleles at Obwq1 confer increased body weightand mesenteric fat pad weight with a dominant mode of inheritance. Previously identified obesity QTL mapping near Obwq1 are Fatq1 (62 cM) and Obq8 (69.1 cM).

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)