Obwq2^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Obwq2^NZB/BlNJ
• Name: obesity and body weight QTL 2; NZB/BlNJ
• MGI ID: MGI:3614852
• QTL: Obwq2 Location: unknown Genetic Position: Chr5, cM position of peak correlated region/allele: 42.22 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased body weight and increased inguinal and gonadal fat pad weights compared to SM/J. (J:103841)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

On mouse Chromosome 5, Adip13 maps to 26 cM near D5Mit81 (LOD=2.9) with a 95% confidence interval spanning 8 cM - 44 cM. NZB/BlNJ-derived alleles at Adip13 confer increased gonadal fat pad weight with an additive mode of inheritance. Nobq1 (28 cM) andObq11 (10 cM) are previously identified obesity QTL mapping near the Adip13 interval.

Obwq2 maps to 44 cM near D5Mit204 (LOD=3.7) with the 95% confidence interval spanning approximately 16 cM - 66 cM.NZB/BlNJ-derived alleles at Obwq2 confer increased body weight and inguinal and gonadal fat pad weights with a dominant mode of inheritance. Previously identified QTL mapping near Obwq2 are Nobq1 (28 cM) and Obq11 (10 cM).

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)