Bwtq8^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Bwtq8^NZB/BlNJ
• Name: body weight QTL 8; NZB/BlNJ
• MGI ID: MGI:3614869
• QTL: Bwtq8 Location: unknown Genetic Position: Chr2, cM position of peak correlated region/allele: 42.74 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased lean body weight compared to SM/J. (J:103841)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Bwtq8 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

On mouse Chromosome 2, Adip10 maps to 2 cM near D2Mit1 (LOD=3.5) with a 95% confidence interval spanning approximately 0 cM - 34 cM. SM/J-derived alleles at Adip10 confer increased inguinal and retroperitoneal fat pad weights with an additive mode of inheritance. Previously identified obesity QTL Obq3 (53 cM), Mob6 (49.6 cM), and Fob1 (45 cM) maps near the Adip10 interval.

Bwtq8 maps to 42 cM near D2Mit92 (LOD=4) with a 95% confidence interval spanning approximately 34 cM - 78 cM. NZB/BlNJ-derived alleles at Bwtq8 confer increased lean body weight with and additive mode of inheritance. Bwq5 (81.7 cM), Nidd5 (34.5 cM), and Pbwg1 (32.8 cM) are previously identified body weight QTL located near Bwtq8.

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)