Bwtq10^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Bwtq10^NZB/BlNJ
• Name: body weight QTL 10; NZB/BlNJ
• MGI ID: MGI:3614877
• QTL: Bwtq10 Location: unknown Genetic Position: Chr6, cM position of peak correlated region/allele: 74.64 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased lean body weight compared to SM/J. (J:103841)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

On mouse Chromosome 6, Bwtq10 maps to 62 cM near D6Mit259 (LOD=5.3) with the 95% confidence interval spanning approximately 52 cM - 70 cM. NZB/BlNJ-derived alleles at Bwtq10 confer increased lean body weight with an additive mode of inheritance.

An obesity locus named Obwq3 maps to 42 cM near D6Mit105 (LOD=5.8) with a 95% confidence interval spanning approximately 30 cM - 66 cM. SM/J-derived alleles at Obwq3 confer increased body weight and increased inguinal and retroperitoneal fat pad weight with a recessive mode of inheritance. Adip2 (43.6 cM) and Obq14 (43.5 cM) are previously identified obesity QTL mapping near Obwq3.

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)