Bwtq12^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Bwtq12^NZB/BlNJ
• Name: body weight QTL 12; NZB/BlNJ
• MGI ID: MGI:3614885
• QTL: Bwtq12 Location: unknown Genetic Position: Chr15, cM position of peak correlated region/allele: 30.86 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased lean body weight compared to SM/J. (J:103841)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Bwtq12 maps to 34 cM on mouse Chromosome 15 near D15Mit90 (LOD=3.1) with a 95% confidence interval spanning approximately 12 cM - 54 cM. NZB/BlNJ-derived alleles confer increased lean body weight with a dominant mode of inheritance.

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)