Obq21^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Obq21^NZB/BlNJ
• Name: obesity QTL 21; NZB/BlNJ
• MGI ID: MGI:3614948
• QTL: Obq21 Location: unknown Genetic Position: Chr18, cM position of peak correlated region/allele: 57.53 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased retroperitoneal fat pad weight compared to SM/J. (J:103841)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Obq21 maps to 54 cM on mouse Chromosome 18 near D18Mit4 (LOD=2.5) with a 95% confidence interval spanning approximately 22 cM - 56 cM. NZB/BlNJ-derived alleles at Obq21 confer increased retroperitoneal fat pad weight with a dominant mode of inheritance.

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)