Del(11Irf1-D11Mit23)1Rub
Targeted Allele Detail

Summary

• Symbol: Del(11Irf1-D11Mit23)1Rub
• Name: deletion, Chr 11, Edward M Rubin 1
• MGI ID: MGI:3614966
• Synonyms: del¹¹, Del(11Irf1-Csf2)1Rub, Del1Rub
• Gene: Del(11Irf1-D11Mit23)1Rub Location: Chr11:53660841-54126873 bp Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60187
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Intergenic deletion, Intragenic deletion
• Del(11Irf1-D11Mit23)1Rub involves 16 genes/genome features (Irf1, Gm17334, Gm12216 ...) View all
• Mutation details: This engineered 450 kb deletion encompasses exon 10 of Irf1, all of Csf2 and approximately 2 kb of downstream DNA, and 9 known or putative genes between these loci on mouse Chr 11 and/or the homologous region of human Chr 5q31. (J:60187)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(11Irf1-D11Mit23)1Rub Mutation: 1 strain or line available

Notes

Mice homozygous for this deletion and hemizygous for the human YAC transgene Tg(A94G6)1Rub were indistinguishable from wild-type control animals for body weight, liver size, heart size, life span, plasma and hepatic triglyceride levels, and hepatic VLDL triglyceride secretion. As SLC22A5 is the only entire gene present in this transgene, but not in others that failed to complement the homozygous deletion phenotype, the phenotype of Del11Irf1-Csf2)1Rub homozygotes is attributed to loss of this gene.

References

• Original: J:60187 Zhu Y, et al., Genomic interval engineering of mice identifies a novel modulator of triglyceride production. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1137-42
• All: 1 reference(s)