Adip12^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Adip12^NZB/BlNJ
• Name: adiposity 12; NZB/BlNJ
• MGI ID: MGI:3614972
• QTL: Adip12 Location: Chr4:141621281-141621387 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 74.75 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Adip12 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

On mouse Chromosome 4, Adip11 maps to 46 cM (D4Mit26, LOD=3.2) with a 95% confidence interval spanning 30 cM - 68 cM. SM/J-derived alleles at Adip11 confer increased inguinal and retroperitoneal fatpad weights with dominant inheritance. Adip11 appears central to a network of interacting loci, which include Obq22 (34 cM, chrX), Obwq3 (42 cM, chr6), and Bwtq12 (34 cM, chr15). Potential candidate genes for Adip11 include Cdkn2a (42.7 cM), Ifnb1 (42.6 cM), Jun (44.6 cM), Rraga, and Lepr (46.7 cM).

Adip12 maps to 70 cM (D4Mit312, LOD=2.6) with a 95% confidence interval spanning 52 cM - 80 cM. SM/J-derived alleles at Adip12 confer increased mesenteric fat pad weight with an additive mode of inheritance. Previously identified obesity QTL Dob1 (50 cM), Pfat1 (30 cM), Afw2 (66 cM), Afpq2 (66 cM) map near Adip11 and Adip12.

Bwtq9 maps to 24 cM near D4Mit44 (LOD=2.1) with a 95% confidence interval spanning approximately 0 cM - 44 cM. NZB/BlNJ-derived alleles at Bwtq9 confer increased lean body weight with a dominant mode of inheritance. Bw8q2 (66 cM) and Bwq1 (6.3 cM) are previously identified body weight QTL located near Bwtq9.

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)