Adip14^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Adip14^NZB/BlNJ
• Name: adiposity 14; NZB/BlNJ
• MGI ID: MGI:3614987
• QTL: Adip14 Location: unknown Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Heterozygous animals exhibit increased retroperitoneal fat pad weight compared to homozygotes. (J:103841)
• Inheritance: Other (see notes)

Notes

Adip14 exhibits overdominance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Adip14 maps to 60 cM on mouse Chromosome 9 near D9Mit15 (LOD=3.9) with a 95% confidence interval spanning 48 cM - 60 cM. Adip14 exhibits overdominance as heterozygous animals exhibit increased retroperitoneal fat pad weights compared to SM/J or NZB/BlNJ homozygotes. Previously identified adiposity QTL Adip5 (42 cM) maps near the Adip14 interval.

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)