Adip15^SM/J
QTL Variant Detail

Summary

• QTL variant: Adip15^SM/J
• Name: adiposity 15; SM/J
• MGI ID: MGI:3614991
• QTL: Adip15 Location: unknown Genetic Position: Chr10, cM position of peak correlated region/allele: 46.85 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Heterozygous animals exhibit increased mesenteric fat pad weight compared to homozygotes. (J:103841)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Adip15 exhibits overdominance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Adip15 maps to 52 cM on mouse Chromosome 10 near D10Mit10 (LOD=3.2) with a 95% confidence interval spanning 46 cM - 66 cM. Adip15 exhibits overdominance as heterozygous animals exhibit increased mesenteric fat pad weights compared to SM/J or NZB/BlNJ homozygotes. Previously identified fat pad QTL Scfpq1 (33.1 cM) is located near the Adip15 interval. Hdlq26 (70 cM) and Pltpq2 (65 cM) also map near Adip15.

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)