Adip16^SM/J
QTL Variant Detail

Summary

• QTL variant: Adip16^SM/J
• Name: adiposity 16; SM/J
• MGI ID: MGI:3615001
• QTL: Adip16 Location: unknown Genetic Position: Chr12, cM position of peak correlated region/allele: 30.06 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased inguinal and gonadal fat pad weights compared to NZB/BlNJ. (J:103841)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

On mouse Chromosome 12, Adip16 maps to 26 cM near D12Mit91 (LOD=5.3) with a 95% confidence intervals spanning 12 cM -32 cM. SM/J-derived alleles at Adip16 confer increased inguinal and gonadal fat pad weights with a dominant mode of inheritance. Previously identified obesity QTL Afpq10 (18 cM), Afw10 (21 cM), Fob2 (19 cM), and Mob3 (53 cM) map near the Adip16 interval.

Bwtq11 maps to 54 cM on mouse Chromosome 12 near D12Mit19 (LOD=4.3) with a 95% confidence interval spanning approximately 42 cM - 58 cM. NZB/BlNJ-derived alleles at Bwtq12 confer increased lean body weight with an additive mode of inheritance. Previously identified adiposity QTL Adip6 (45 cM) maps near Bwtq11.

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)