Adip17^SM/J
QTL Variant Detail

Summary

• QTL variant: Adip17^SM/J
• Name: adiposity 17; SM/J
• MGI ID: MGI:3615111
• QTL: Adip17 Location: unknown Genetic Position: Chr16, cM position of peak correlated region/allele: 2.33 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased inguinal, gonadal, and retroperitoneal fat pad weights compared to NZB/BlNJ. (J:103841)
• Inheritance: Other (see notes)

Notes

Adip17 exhibit additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Adip17 maps to 0 cM on mouse Chromosome 16 near D16Mit32 (LOD=2.4) with a 95% confidence interval spanning 0 cM - 34 cM. SM/J-derived alleles confer increased inguinal, gonadal, and retroperitoneal fat pad weights with an additive mode of inheritance.

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)