Adip18^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Adip18^NZB/BlNJ
• Name: adiposity 18; NZB/BlNJ
• MGI ID: MGI:3615116
• QTL: Adip18 Location: unknown Genetic Position: Chr17, cM position of peak correlated region/allele: 7.78 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased inguinal and gonadal fat pad weights compared to SM/J. (J:103841)
• Inheritance: Other (see notes)

Notes

Adip18 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

On mouse Chromosome 17, Adip18 maps to 10 cM near D17Mit58 (LOD=2.9) with a 95% confidence interval spanning approximately 0 cM - 18 cM. NZB/BlNJ-derived alleles at Adip18 confer increased inguinal and gonadal fat pad weights with an additive mode of inheritance. Previously identified obesity QTL Afpq6 (36 cM) and Obq4 (4 cM) map near Adip18.

Obwq4 maps to 32 cM on mouse Chromosome 17 near D17Mit20 (LOD=6.8) with a 95% confidence interval spanning approximately 20 cM - 44 cM. NZB/BlNJ-derived alleles at Obwq4 confer increased body weight and all fat pad weight with an additive mode of inheritance. Previously identified obesity QTL mapping near Obwq4 include Afpq6 (36 cM), Obq4 (4 cM), Scfq4 (21.9cM), and Epfq4 (17.4 cM). Obwq4 appears central to a network of interacting loci, which involves Bfq1 (81 cM) on mouse Chromosome 2. Tgif is a potential candidate gene for Obwq4.

References

• Original: J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
• All: 1 reference(s)