Bhlha15^tm2(Kras)Skz
Targeted Allele Detail

Summary

• Symbol: Bhlha15^tm2(Kras)Skz
• Name: basic helix-loop-helix family, member a15; targeted mutation 2, Stephen F Konieczny
• MGI ID: MGI:3615274
• Synonyms: Mist1^KrasG12D
• Gene: Bhlha15 Location: Chr5:144127104-144131259 bp, + strand Genetic Position: Chr5, 83.05 cM, cytoband G2-G3
• Alliance: Bhlha15^tm2(Kras)Skz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105076
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Kras cDNA with a G12D mutation and a PGK-neo cassette were inserted into the locus downstream of the ATG in exon 2 in-frame. (J:105076)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bhlha15 Mutation: 15 strains or lines available

References

• Original: J:105076 Tuveson DA, et al., Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Res. 2006 Jan 1;66(1):242-7
• All: 6 reference(s)