Rab3b^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Rab3b^tm1Sud
• Name: RAB3B, member RAS oncogene family; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:3615355
• Gene: Rab3b Location: Chr4:108736267-108800521 bp, + strand Genetic Position: Chr4, 50.67 cM, cytoband C7
• Alliance: Rab3b^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105478
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1, encoding residues 1-76, with a neomycin resistance cassette. Absence of protein was confirmed in immunoblot analysis of mutant brain samples. (J:105478)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rab3b Mutation: 12 strains or lines available

References

• Original: J:105478 Schluter OM, et al., A complete genetic analysis of neuronal Rab3 function. J Neurosci. 2004 Jul 21;24(29):6629-37
• All: 7 reference(s)