Apbb2^tm1Her
Targeted Allele Detail

Summary

• Symbol: Apbb2^tm1Her
• Name: amyloid beta precursor protein binding family B member 2; targeted mutation 1, Joachim Herz
• MGI ID: MGI:3615374
• Synonyms: Apbb2^tm1Sgnt, Fe65l1^-
• Gene: Apbb2 Location: Chr5:66456046-66776127 bp, - strand Genetic Position: Chr5, 34.43 cM
• Alliance: Apbb2^tm1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105160
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace 692 nucleotides of exon 4 with a tau-LacZ fusion protein and a neo cassette. Protein was not detected by Western blot analysis. (J:105160)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apbb2 Mutation: 66 strains or lines available

References

• Original: J:105160 Guenette S, et al., Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J. 2006 Jan 25;25(2):420-31
• All: 3 reference(s)