Chrng^{tm1(Chrne)Mknn}
Targeted Allele Detail

Summary

• Symbol: Chrng^{tm1(Chrne)Mknn}
• Name: cholinergic receptor, nicotinic, gamma polypeptide; targeted mutation 1, Michael Koenen
• MGI ID: MGI:3615397
• Synonyms: AChRgamma^epsilon
• Gene: Chrng Location: Chr1:87133533-87139365 bp, + strand Genetic Position: Chr1, 44.07 cM
• Alliance: Chrng^{tm1(Chrne)Mknn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105142
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a sequence containing the N-terminal 133 amino acids of Chrng fused to 382 amino acids of Chrne, including transmembrane segments 1-4. Mutants lacked endogenous transcripts at birth, however, mutant transcript levels matched levels of other cholinergic receptor subunits. Mutant transcript levels then decreased during postnatal development, as expected for regulatory sequences in the endogenous locus. (J:105142)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrng Mutation: 31 strains or lines available

References

• Original: J:105142 Koenen M, et al., Acetylcholine receptor channel subtype directs the innervation pattern of skeletal muscle. EMBO Rep. 2005 Jun;6(6):570-6
• All: 1 reference(s)