Exa^BALB/cBy
QTL Variant Detail

Summary

• QTL variant: Exa^BALB/cBy
• Name: exploratory activity; BALB/cBy
• MGI ID: MGI:3615635
• QTL: Exa Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: BALB/cBy

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased exploratory activity compared to C57BL/6By. (J:5355)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:5355

Inbred strain C57BL/6By exhibits higher short term exploratory activity compared to inbred strain BALB/cBy. However, this phenotype is reversed when animals are administered scopolomine in that BALB/cBy now exhibits higher short term exploratory activitycompared to C57BL/6By. Analysis of 7 CXB (C=BALB/cBy; B=C57BL/6By) recombinant inbred (RI) strains mapped A QTL named Scom (scopolamine modification of exploratory activity) near the H2 locus at 23 cM on mouse Chromosome 17.

A previously identified QTL named Exa (exploratory activity) mapped to mouse Chromosome 4 in congenic line H(w26) derived from BALB/cBy donor and C57BL/6By recipient strains. The congenic exhibits low exploratory activity similar to the BALB/cBy donor strain, indicating that Exa exhibits decreased exploratory activity when derived from BALB/cBy.

References

• Original: J:5355 Oliverio A, et al., Exploratory activity: genetic analysis of its modification by scopolamine and amphetamine. Physiol Behav. 1973 May;10(5):893-9
• All: 1 reference(s)