Gdcr1^BALB/cJ
QTL Variant Detail

Summary

• QTL variant: Gdcr1^BALB/cJ
• Name: glycerolphosphate dehydrogenase regulator 1; BALB/cJ
• MGI ID: MGI:3615639
• QTL: Gdcr1 Location: Chr15:99615474-99622889 bp Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: BALB/cJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased cerebellar mRNA expression of Gpd1 compared to C57BL/6J. (J:7860)

Notes

This allele acts in cis and preferentially increases expression from the BALB/cJ Gpd1 allele.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7860

Parental strain BALB/cJ exhibits increased cerebellar Gpd1 mRNA expression and enzyme stability compared to parental strain C57BL/6J. Using a series of CXB (C=BALB/cJ; B=C57BL/6J) recombinant inbred (RI) strains, a locus named Gdcr1 (glycerolphosphate dehydrogenase regulator 1) affecting cerebellar Gpd1 mRNA expression mapped to mouse Chromosome 15 and shows linkage with the Gpd1 structural gene at 56.8 cM. The BALB/cJ-derived allele of Gdcr1 acts in cis by preferentially increasing mRNA expression of the BALB/cJ allele of Gpd1.

A second unlinked locus named Gdcr2 (glycerolphosphate dehydrogenase regulator 2) affects cerebellar Gpd1 expression from either allele. CXB RI strain analysis and analysis of CXB x (CXB x B6.CAST)F1 backcross animals shows thatGdcr2 is not linked to Gpd1 or Gdcr1 on chromosome 15. The strain distribution pattern of Gdcr2 suggests possible linkage to Es1 (43 cM) on chromosome 8, Glb1 (66 cM) on chromosome 9, H18 (74.5 cM) on chromosome 4, or H35 on chromosome 1.

References

• Original: J:7860 Kozak LP, Interacting genes control glycerol-3-phosphate dehydrogenase expression in developing cerebellum of the mouse. Genetics. 1985 May;110(1):123-43
• All: 1 reference(s)