Arp^C57BL/10
QTL Variant Detail

Summary

• QTL variant: Arp^C57BL/10
• Name: Arp lymphoid/erythroid hyperplasia; C57BL/10
• MGI ID: MGI:3615650
• QTL: Arp Location: Chr5:45650716-45670033 bp Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: C57BL/10

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7273

Genetic screening of (B10.D2-H2^d x BALB/c)F1 x BALB/c backcross animals revealed linkage between Arp (Arp lymphoid/erythroid hyperplasia) and Lap3 (formerly Pep7) at 67 cM on mouse Chromosome 5. The BALB/c allele of Arp is associated with induction of lymphoproliferative disease. Arp^BALB/c is also associated a Lap3 protein polymorphism exhibiting faster mobility compared to the C57BL/10 variant. Arp interacts with a separate locus named Lus (lymphoid cytostasis suppressor) for development of lymphoproliferative disease.

References

• Original: J:7273 Matossian-Rogers A, et al., Alloimmune interactions of a lymphoproliferative disease-inducer gene Arp and linkage to Pep-7. Immunogenetics. 1983;18(6):639-48
• All: 1 reference(s)