Mclr^SWR/J
QTL Variant Detail

Summary

• QTL variant: Mclr^SWR/J
• Name: methylcholanthrene lymphoma resistance; SWR/J
• MGI ID: MGI:3615656
• QTL: Mclr Location: Chr6:71350411-71356155 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: SWR/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to 3-methylcholanthrene induced T-cell lymphoma compared to RF/J. (J:9614)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:9614

A single locus associated with resistance to 3-methylcholanthrene (MCA)-induced T-cell lymphoma was mapped in (SWR/J x RF/J)F1 x RF/J backross animals. Parental strain SWR/J is resistant to MCA-induced lymphoma where as parental strain RF/J is susceptible. Mclr (methylcholanthrene lymphoma resistance) mapped to mouse Chromosome 6 and shows linkage to Cd8a (formerly Lyt-2) at 30.5 cM. SWR/J-derived alleles at Mclr confer dominantly-inherited resistance to MCA-induced T-cell lymphomaS.

References

• Original: J:9614 Ishizaka ST, et al., Genetic control of resistance to 3-methylcholanthrene-induced T-cell lymphoma in mice. Cancer Res. 1989 Mar 1;49(5):1214-9
• All: 1 reference(s)