Tg(Atoh1-cre/Esr1*)14Fsh
Transgene Detail

Summary

• Symbol: Tg(Atoh1-cre/Esr1*)14Fsh
• Name: transgene insertion 14, Gordon Fishell
• MGI ID: MGI:3615691
• Synonyms: Atoh1-cre, Math1-cre, Math1-CreER^T2, Tg(Atoh1-cre/ESR1)1Fsh, Tg(HBB-cre)1Fsh
• Transgene: Tg(Atoh1-cre/Esr1*)14Fsh Location: unknown
• Alliance: Tg(Atoh1-cre/Esr1*)14Fsh page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Atoh1-cre/Esr1*)14Fsh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Atoh1 (MGI:104654)

• Mutation details: The transgene was designed with a 1.4 kb mouse Math1 (Atoh1) 3' enhancer (and a beta-globin minimal promoter) sequence upstream of a CreERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Tamoxifen-inducible cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordia (with a limited amount of ectopic expression in the primordium of the hippocampus but not the cortex). (J:105186)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Atoh1 (mouse) Summary of all recombinase alleles driven by Atoh1. Comparative matrix view of recombinase activities Alliance mouse Atoh1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

2 assay results

Tumor Data

List all tumor models in MMHCdb carrying Tg(Atoh1-cre/Esr1*)14Fsh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:105186 Machold R, et al., Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors. Neuron. 2005 Oct 6;48(1):17-24
• All: 70 reference(s)