Gpr3^tm1Cled
Targeted Allele Detail

Summary

• Symbol: Gpr3^tm1Cled
• Name: G-protein coupled receptor 3; targeted mutation 1, Catherine Ledent
• MGI ID: MGI:3615760
• Synonyms: Gpr3^-
• Gene: Gpr3 Location: Chr4:132936651-132939847 bp, - strand Genetic Position: Chr4, 66.24 cM, cytoband D3
• Alliance: Gpr3^tm1Cled page

Oocytes from superovulated Gpr3^tm1Cled/Gpr3^tm1Cled females display age-dependent increase in fragmentation

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105182
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the entire coding sequence with a neomycin resistance cassette in reverse orientation. (J:105182)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr3 Mutation: 22 strains or lines available

References

• Original: J:105182 Ledent C, et al., Premature ovarian aging in mice deficient for Gpr3. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8922-6
• All: 3 reference(s)