Hoxd1^tm1Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd1^tm1Ddu
• Name: homeobox D1; targeted mutation 1, Denis Duboule
• MGI ID: MGI:3616015
• Synonyms: L11, TgH(d1/lac)Ge
• Gene: Hoxd1 Location: Chr2:74593324-74595486 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Hoxd1^tm1Ddu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70547
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: This allele was created in the same ES cells used to create Hoxd^tm2.1Ddu and thus has a loxP site located 5' of Hoxd13. A lacZ reporter sequence followed by a PGKneo selection cassette was inserted into exon 2. In vitro cre expression removed the selection cassette only. The resulting fusion protein expressed all but the most C-terminal 25 amino acids. (J:70547)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd1 Mutation: 16 strains or lines available

References

• Original: J:70547 Zakany J, et al., Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock. Cell. 2001 Jul 27;106(2):207-17
• All: 1 reference(s)