Hoxd^{tm21(Hoxd11)Ddu}
Targeted Allele Detail

Summary

• Symbol: Hoxd^{tm21(Hoxd11)Ddu}
• Name: homeobox D cluster; targeted mutation 21, Denis Duboule
• MGI ID: MGI:3616018
• Synonyms: del(1-13), Del1Ddu, Del(2Hoxd1-Hoxd13)1Ddu, TgH(d11/lac/Del9)Ge
• Gene: Hoxd Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70547
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Hoxd^{tm21(Hoxd11)Ddu} involves 16 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
• Mutation details: This allele was created in the same ES cells used to create Hoxd^{tm18.1(Hoxd11)Ddu} and thus has a Hoxd11/lacZ/loxP site located 5' of Hoxd13. A lacZ reporter sequence followed by a PGKneo selection cassette was inserted into exon 2 of Hoxd1. In vitro cre expression removed the entire Hoxd cluster replacing it with a Hoxd11/lacZ fusion gene. (J:70547)

Expression

In Mice Carrying this Mutation:	121 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd Mutation: 0 strains or lines available

References

• Original: J:70547 Zakany J, et al., Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock. Cell. 2001 Jul 27;106(2):207-17
• All: 17 reference(s)