Del(2Hoxd10-Hoxd13)10Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd10-Hoxd13)10Ddu
• Name: deletion, Chr 2, Denis Duboule 10
• MGI ID: MGI:3616167
• Synonyms: Del(10-13);Evx2^stop, Del10Ddu
• Gene: Del(2Hoxd10-Hoxd13)10Ddu Location: Chr2:74498654-74525449 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103924
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Hoxd10-Hoxd13)10Ddu involves 4 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
• Mutation details: Produced by targeted meiotic recombination in a cross between Evx2/Hoxd13 and Hoxd in the presence of Tg(Sycp1-cre)4Min. Hoxd10, Hoxd11, Hoxd12, and Hoxd13 are all deleted from the Hoxd cluster. In addition, the Evx2 locus just 5' to the Hoxd cluster has a stop codon in exon 1. (J:103924)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd10-Hoxd13)10Ddu Mutation: 0 strains or lines available

References

• Original: J:103924 Tarchini B, et al., HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside. Genes Dev. 2005 Dec 1;19(23):2862-76
• All: 1 reference(s)