Del(2Hoxd8-Hoxd9)18Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd8-Hoxd9)18Ddu
• Name: deletion, Chr 2, Denis Duboule 18
• MGI ID: MGI:3616254
• Synonyms: Del18Ddu, Del(i-9)
• Gene: Del(2Hoxd8-Hoxd9)18Ddu Location: Chr2:74528107-74538277 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103924
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Hoxd8-Hoxd9)18Ddu involves 3 genes/genome features (Hoxd9, Hoxd8, Hoxd3os1) View all
• Mutation details: Produced by targeted meiotic recombination in a cross between Hoxd^tm13Ddu and Hoxd^tm16Ddu in the presence of Tg(Sycp1-cre)4Min. Both Hoxd8 and Hoxd9 as well as most of the "i" region between Hoxd4 and Hoxd8 are deleted from the Hoxd cluster. (J:103924)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd8-Hoxd9)18Ddu Mutation: 0 strains or lines available

References

• Original: J:103924 Tarchini B, et al., HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside. Genes Dev. 2005 Dec 1;19(23):2862-76
• All: 3 reference(s)