Nox1^tm1Kkr
Targeted Allele Detail

Summary

• Symbol: Nox1^tm1Kkr
• Name: NADPH oxidase 1; targeted mutation 1, Karl-Heinz Krause
• MGI ID: MGI:3616995
• Gene: Nox1 Location: ChrX:132987170-133038455 bp, - strand Genetic Position: ChrX, 55.69 cM
• Alliance: Nox1^tm1Kkr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105425
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 1.9 Kb fragment of the NOX1 gene which encodes exons 3 to 6. RT-PCR confirmed mRNA was absent from the aorta of the hemizygous male mice. (J:105425)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nox1 Mutation: 12 strains or lines available

References

• Original: J:105425 Gavazzi G, et al., Decreased blood pressure in NOX1-deficient mice. FEBS Lett. 2006 Jan 23;580(2):497-504
• All: 66 reference(s)