Plp1^tm3Wst
Targeted Allele Detail

Summary

• Symbol: Plp1^tm3Wst
• Name: proteolipid protein (myelin) 1; targeted mutation 3, Wilhelm Stoffel
• MGI ID: MGI:3617313
• Synonyms: dm20only
• Gene: Plp1 Location: ChrX:135723420-135740482 bp, + strand Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
• Alliance: Plp1^tm3Wst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105188
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A targeting vector was designed to delete 105 bp of exon 3. Transcription of Plp1 was reduced by 50-60%, however, DM20 protein was expressed at wild-type levels. (J:105188)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plp1 Mutation: 18 strains or lines available

References

• Original: J:105188 Sporkel O, et al., Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development. Glia. 2002 Jan;37(1):19-30
• All: 1 reference(s)