Pkd1^tm2.1Ggg
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm2.1Ggg
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2.1, Gregory G Germino
• MGI ID: MGI:3617325
• Synonyms: Pkd1^del2-4
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm2.1Ggg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103719
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated by breeding mice carrying Pkd1^tm2Ggg with Meox2^tm1(cre)Sor mice that express cre in the germline. Cre-mediated recombination removed exons 2 to 4. RT-PCR shows that mutant transcripts lack exons 2-4. (J:103719)

Disease models

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

References

• Original: J:103719 Piontek KB, et al., A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol. 2004 Dec;15(12):3035-43
• All: 11 reference(s)