Notch2^tm3Grid
Targeted Allele Detail

Summary

• Symbol: Notch2^tm3Grid
• Name: notch 2; targeted mutation 3, Tom Gridley
• MGI ID: MGI:3617328
• Synonyms: N2^f, N2^flox, Notch2^f, Notch2^Fl, Notch2^flox
• Gene: Notch2 Location: Chr3:97920854-98057683 bp, + strand Genetic Position: Chr3, 42.42 cM
• Alliance: Notch2^tm3Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105278
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• loxP sites were inserted to flank exon 3. (J:105278)

Disease models

Expression

In Mice Carrying this Mutation:	110 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Notch2 Mutation: 99 strains or lines available

References

• Original: J:105278 McCright B, et al., Generation of new Notch2 mutant alleles. Genesis. 2006 Jan;44(1):29-33
• All: 88 reference(s)