Tuba1a^Jna
Chemically induced Allele Detail

Summary

• Symbol: Tuba1a^Jna
• Name: tubulin, alpha 1A; jenna
• MGI ID: MGI:3617352
• Synonyms: Gena227
• Gene: Tuba1a Location: Chr15:98847728-98851382 bp, - strand Genetic Position: Chr15, 55.29 cM
• Alliance: Tuba1a^Jna page

Mutation origin

• Strain of Origin: BALB/cAnN
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: This phenotypic mutation was identified in an ENU mutagenesis screen and contains a mutation that causes an amino acid change from serine to glycine at residue 140. This mutation reduced GTP binding and native heterodimer formation. (J:117881)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tuba1a Mutation: 15 strains or lines available

References

• Original: J:117881 Keays DA, et al., Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell. 2007 Jan 12;128(1):45-57
• All: 6 reference(s)