Kpnb1^{Gt(pU-hachi)1Arak}
Gene trapped Allele Detail

Summary

• Symbol: Kpnb1^{Gt(pU-hachi)1Arak}
• Name: karyopherin subunit beta 1; gene trap 1, Kimi Araki
• MGI ID: MGI:3617354
• Synonyms: Ayu8108^geo, Ayu8108^Gtgeo1MEG
• Gene: Kpnb1 Location: Chr11:97050540-97078707 bp, - strand Genetic Position: Chr11, 60.95 cM, cytoband D
• Alliance: Kpnb1^{Gt(pU-hachi)1Arak} page

Mutation origin

• Mutant Cell Line: AYU8-108
• Germline Transmission: Earliest citation of germline transmission: J:105350
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The pU-hachi gene trap vector, containing an IRES-betageo, was inserted into the promoter region of the locus in reverse orientation of transcription. This vector was designed to be exchangeable upon cre expression. Expression of the endogenous locus was decreased by about 60-80% of wild-type, demonstrating this allele is a hypomorph. (J:105350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kpnb1 Mutation: 57 strains or lines available

References

• Original: J:105350 Miura K, et al., Impaired expression of importin/karyopherin beta1 leads to post-implantation lethality. Biochem Biophys Res Commun. 2006 Mar 3;341(1):132-8
• All: 1 reference(s)