Kpnb1^{Gt(Kpnb1)2Arak}
Gene trapped Allele Detail

Summary

• Symbol: Kpnb1^{Gt(Kpnb1)2Arak}
• Name: karyopherin subunit beta 1; gene trap 2, Kimi Araki
• MGI ID: MGI:3617356
• Synonyms: Ayu8108^Impbeta, Kpnb1^{Gt(Kpnb1)1.1Arak}, Kpnb1^{tm1(Kpnb1)Arak}
• Gene: Kpnb1 Location: Chr11:97050540-97078707 bp, - strand Genetic Position: Chr11, 60.95 cM, cytoband D
• Alliance: Kpnb1^{Gt(Kpnb1)2Arak} page

Mutation origin

• Mutant Cell Line: AYU8-108
• Germline Transmission: Earliest citation of germline transmission: J:105350
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Gene trapped (Inserted expressed sequence)
• Mutation: Insertion of gene trap vector
• Mutation details: ES cells containing the Kpnb1^{Gt(pU-hachi)1Arak} allele were targeted with a cre plasmid and a vector containing Kpnb1 cDNA, resulting in the replacement of the IRES-betageo within the gene trap vector with Kpnb1 cDNA, and PGK-puro. Mutants expressed both the endogenous and inserted sequences. (J:105350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kpnb1 Mutation: 57 strains or lines available

References

• Original: J:105350 Miura K, et al., Impaired expression of importin/karyopherin beta1 leads to post-implantation lethality. Biochem Biophys Res Commun. 2006 Mar 3;341(1):132-8
• All: 1 reference(s)