Acaa1b^tm1Vnf
Targeted Allele Detail

Summary

• Symbol: Acaa1b^tm1Vnf
• Name: acetyl-Coenzyme A acyltransferase 1B; targeted mutation 1, Valerie Nicolas-Frances
• MGI ID: MGI:3617359
• Synonyms: mThB^-
• Gene: Acaa1b Location: Chr9:118977111-118986149 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Acaa1b^tm1Vnf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105494
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence of 2.3 kb spanning from exon 2 to intron 3 was replaced with a GFP-neo construct. Northern blot failed to detect wild-type transcript in mutants. (J:105494)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Acaa1b Mutation: 14 strains or lines available

References

• Original: J:105494 Chevillard G, et al., Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism. Biochimie. 2004 Nov;86(11):849-56
• All: 2 reference(s)