Dclk1^tm1.1Jgg
Targeted Allele Detail

Summary

• Symbol: Dclk1^tm1.1Jgg
• Name: doublecortin-like kinase 1; targeted mutation 1.1, Joseph G Gleeson
• MGI ID: MGI:3617379
• Synonyms: Dclk^-
• Gene: Dclk1 Location: Chr3:55149785-55446489 bp, + strand Genetic Position: Chr3, 26.53 cM, cytoband D
• Alliance: Dclk1^tm1.1Jgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105300
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination was used to remove exon 3. Removal of this exon is predicted to result in splicing of exon 2 to a downstream exon, resulting in out-of-frame splicing. Exon 3 encodes the majority of the R1 repeat. Mutants demonstrated abolishment of isoforms containing the DCX domain. (J:105300)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dclk1 Mutation: 55 strains or lines available

References

• Original: J:105300 Koizumi H, et al., Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Neuron. 2006 Jan 5;49(1):55-66
• All: 3 reference(s)