Gabra1^tm2Geh
Targeted Allele Detail

Summary

• Symbol: Gabra1^tm2Geh
• Name: gamma-aminobutyric acid type A receptor subunit alpha 1; targeted mutation 1, Gregg E Homanics
• MGI ID: MGI:3617384
• Synonyms: Hneo
• Gene: Gabra1 Location: Chr11:42021766-42073757 bp, - strand Genetic Position: Chr11, 24.97 cM
• Alliance: Gabra1^tm2Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105293
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to replace serine at position 270, within exon 8, to histidine (S270H). An FRT-flanked neo was included in the construct. (J:105293)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra1 Mutation: 48 strains or lines available

References

• Original: J:105293 Homanics GE, et al., A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse. Genes Brain Behav. 2005 Feb;4(1):10-9
• All: 1 reference(s)