Snai1^tm2Grid
Targeted Allele Detail

Summary

• Symbol: Snai1^tm2Grid
• Name: snail family zinc finger 1; targeted mutation 1, Tom Gridley
• MGI ID: MGI:3617387
• Synonyms: Snai1^flox
• Gene: Snai1 Location: Chr2:167380115-167384734 bp, + strand Genetic Position: Chr2, 87.33 cM
• Alliance: Snai1^tm2Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105294
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank promoter sequences, exons 1 and 2. The frt flanked neo cassette was removed by flp mediated recombination. Deletion of this sequence would remove the start codon, the 5' SNAG repression domain and the first three zinc finger DNA binding domains of the protein. (J:105294)

Expression

In Mice Carrying this Mutation:	86 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snai1 Mutation: 11 strains or lines available

References

• Original: J:105294 Murray SA, et al., Generation of a Snail1 (Snai1) conditional null allele. Genesis. 2006 Jan;44(1):7-11
• All: 20 reference(s)