Snrpn^tm5Alb
Targeted Allele Detail

Summary

• Symbol: Snrpn^tm5Alb
• Name: small nuclear ribonucleoprotein N; targeted mutation 5, Arthur L Beaudet
• MGI ID: MGI:3617407
• Gene: Snrpn Location: Chr7:59632243-59789967 bp, - strand Genetic Position: Chr7, 34.04 cM
• Alliance: Snrpn^tm5Alb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105289
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: ES cells containing Rr70 were targeted with a second vector, inserting a loxP site and exons 1-2 of the Hprt minigene about 93 kb upstream of exon 1. Transient expression of cre recombinase resulted in the excision of the 80 kb sequence between the two loxP sites. (J:105289)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snrpn Mutation: 23 strains or lines available

References

• Original: J:105289 Wu MY, et al., Mouse imprinting defect mutations that model Angelman syndrome. Genesis. 2006 Jan;44(1):12-22
• All: 1 reference(s)