mwfh^C3HeB/FeJLe
QTL Variant Detail

Summary

• QTL variant: mwfh^C3HeB/FeJLe
• Name: modifier of white forlock hypopigmentation; C3HeB/FeJLe
• MGI ID: MGI:3617475
• QTL: mwfh Location: Chr10:100017003-100017136 bp Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: C3HeB/FeJLe

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased incidence of white forelock hypopigmentation compared to C57BL/6JLe. (J:53978)
• Inheritance: Recessive

Notes

This locus modifies the hypopigmentation phenotype of the Sox10^Dom> mutation.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53978

A phenotypic trait of the Sox^Dom mutation in mice is hypopigmentation. Analysis of congenic lines derived on either a C57BL/6JLe or C3HeB/FeJLe-a/a background indicate that the degree of spotting (hypopigmentation) varies between the congenics.

A search for modifer loci effecting the degree of hypopigmentation (white forelock) was initiated in genetic crosses involving the Sox^Dom congenics with B6C3F1/J mice. The results indicated that a modifier locus named mwfh (modifier of white forelock hypopigmentation) showed significant linkage with Chromosome 10 microsatellite marker D10Mit178 at 59 cM (LOD=5.63). Sox^Dom/+ F2 animals homozygous for C3HeB/FeJLe-derived alleles at mwfh exhibit increased incidence of white forelock. This locus appears to exhibit recessive inheritance with reduced penetrance. Mwfh maps to the same region as a modifier locus that effects hypopigmentation in Ednrb mice, however the authors could not ascertain whether the two modifiers were identical. A potential candidate gene for mwfh is Kitl(57 cM).

References

• Original: J:53978 Southard-Smith EM, et al., The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. Genome Res. 1999 Mar;9(3):215-25
• All: 1 reference(s)