Tff2^tm1Blin
Targeted Allele Detail

Summary

• Symbol: Tff2^tm1Blin
• Name: trefoil factor 2 (spasmolytic protein 1); targeted mutation 1, Nikolaus Blin
• MGI ID: MGI:3617545
• Synonyms: TFF2^-
• Gene: Tff2 Location: Chr17:31360036-31363256 bp, - strand Genetic Position: Chr17, 15.8 cM
• Alliance: Tff2^tm1Blin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105277
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1 and 2. Absence of transcript and protein was confirmed by Northern and Western blot, respectively. (J:105277)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tff2 Mutation: 12 strains or lines available

References

• Original: J:105277 Baus-Loncar M, et al., Trefoil factor 2 (TFF2) deficiency in murine digestive tract influences the immune system. Cell Physiol Biochem. 2005;16(1-3):31-42
• All: 1 reference(s)