Rgv1^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Rgv1^C57BL/6
• Name: resistance to Gross virus 1; C57BL/6
• MGI ID: MGI:3617638
• Synonyms: Rgv-1
• QTL: Rgv1 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to Gross virus-induced leukemia compared to C3Hf/Bi. (J:5011)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:5011

Resistance to Gross leukemia virus mapped to mouse Chromosome 17 near the H2 locus (23 cM) in a (C3Hf/Bi x C57BL/6)F2 intercross population. This locus is named Rgv1 (resistance to Gross virus 1). Parental strain C3Hf/Bi carries the k allele at H2 and issusceptible to Gross virus whereas parental strain C57BL/6 carries the b allele at H2 and is highly resistant. Resistance to Gross virus at Rgv1 appears to be dominantly inherited from the C57BL/6 strain. C4b, which maps to 18.8 cM, is a potential candidate gene for Rgv1. A second unlinked locus named Rgv2 is thought to segregate in the F2 population.

References

• Original: J:5011 Lilly F, The inheritance of susceptibility to the Gross leukemia virus in mice. Genetics. 1966 Mar;53(3):529-39
• All: 1 reference(s)